2015;151:256–9.Sevketoglu E, Hatipoglu S, Ayan I, Dogan O, Salihoglu B. 2014;1:1-7.Fujinuma Y, Asahina M, Fukushima T, Katagiri A, Yamanaka Y, Misawa S, et al. Development and validation of Chinese version of female sexual function index in a Chinese population- a pilot study. CQQ participated in data collecting. After 12-month treatment, the mean total FSFI score had increased from 17.1 ± 7.2 to 23.7 ± 7.2(Combination therapy with low-dose lenalidomide plus dexamethasone is successful in improving sexual function in POEMS syndrome.POEMS (polyneuropathy, organomegaly, endocrinopathy, M-spike, skin changes) syndrome is a rare paraneoplastic syndrome characterized with multisystem involvement and markedly increased vascular endothelial growth factor (VEGF) levels [Endocrinopathy is a central but poorly understood feature of POEMS. 1996;347:702.Yokouchi H, Baba T, Misawa S, Sawai S, Kitahashi M, Oshitari T, et al. 2015;95:325–30.Gandhi GY, Basu R, Dispenzieri A, Basu A, Montori VM, Brennan MD. All the participants were married. Fertil Steril. In this single-center prospective study, the efficacy of low-dose lenalidomide and dexamethasone combination therapy in the improvement of sexual and gonadal function in … All participants provided written informed consent prior to their participation.Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaDepartment of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaXufei Huang, Qianqian Cai, Chen Wang, Xinxin Cao, Daobin Zhou & Jian LiYou can also search for this author in Am J Hematol. POEMS syndrome: update on diagnosis, risk-stratification, and management. IIEF is sensitive and specific for detecting treatment-related changes in patients with erectile dysfunction [All blood samples were collected between 7 and 11 AM. Recently, it has been showed that lenalidomide might play a promising role in the treatment of POEMS syndrome [Forty-one consecutive patients with newly diagnosed POEMS syndrome (male 28, female 13) were treated with combination of low-dose lenalidomide and dexamethasone at Peking Union Medical College Hospital from April 2014 to November 2015. In this single-center prospective study, the efficacy of low-dose lenalidomide and dexamethasone combination therapy in the improvement of sexual and gonadal function in POEMS syndrome was evaluated.Thirty-five patients with newly diagnosed POEMS syndrome were treated with Lenalidomide (10 mg daily for 21 days) and dexamethasone (40 mg once per week) for 12 cycles. Lenalidomide, despite its known toxicities, has significantly improved the once-poor prognosis and survival rates of MM. 2015 Oct 26. doi: The authors offer their sincere thanks to all the participants and their families who participated in the clinical trial.This work had been supported by the National Natural Science Foundation of China (no. t-test was used to detect the statistical significance of the Hormone levels, VEGF levels, FSFI and IIEF scores before and after lenalidomide treatment. doi: 10.4084/MJHID.2017.051. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Mean FSFI distribution by domain before and after 12-month combination therapy. Circulating antibodies against hormones or specific hormone receptors have not been found. BioMed Central No association between VEGF levels and sexual function improvement was found in both genders. FSFI: Female Sexual Function Index. The main limitation of this study is the number of participants. Other side effects include:febrile neu… FSFI: Female… Mean IIEF distribution by domain before and after 12-month combination therapy * The arousal, orgasm and sex pain domains had been improved significantly at the end of 12-month treatment (Fig. Blood. 2019 Feb;60(2):483-487. doi: 10.1080/10428194.2018.1485909. All patients met the diagnostic criteria defined by Dispenzieri, with two mandatory criteria (polyneuropathy and monoclonoal plasma cell proliferating disorder), at least one major criterion (sclerotic bone lesion, Castleman disease or VEGF elevation) and one minor criterion (organomegaly, edema, endocrinology, skin change, papillary edema or thrombocytosis) [All patients received lenalidomie (Revlimid; Celgene Corporation, Summit, NJ, USA) at a dose of 10 mg daily for 21 days of a 28-day cycle, plus oral dexamethasone at 40 mg once per week. Multiple myeloma For newly diagnosed cases in patients who are not eligible for transplant: In combination with dexamethasone: Initial: 25 mg once daily on days 1-21 of repeated 28-day cycles. In female patients, the mean total FSFI score had been improved to 23.7 ± 7.2 after 12-month treatment.

You can also search for this author in 2019 Oct;7(4):604-613. doi: 10.1016/j.sxmr.2019.05.005. J Sex Med. 2013;88:207–12.Dispenzieri A. Br J Ophthalmol. 2013110611000).The dataset supporting the conclusions of this article is included within the article.YHB participated in the design of the protocol of endocrine and sexual function assessment and drafted the manuscript. In Mayo Clinic series, about 84 % of patients had a recognized endocrinopathy, with hypogonadism as the most common endocrine abnormality, followed by thyroid dysfunction, abnormal glucose metabolism, and lastly by adrenal insufficiency [Lenalidomide is a derivative of thalidomide, with powerful activity against malignant plasma cells as well as acting to decrease the levels of proinflammatory and proangiogenic cytokines. Blood. We also did not collect data regarding educational status or social economic status.In summary, low-dose lenalidomide plus dexamethasone combination therapy is successful in improving gonadal function in patients with POEMS syndrome.FSFI, female sexual function index FSFI is a 19-item multidimensional self-reporting measure, which quantifies six domains of female sexual dysfunction, including desire, arousal, lubrication, orgasm, satisfaction and pain. POEMS syndrome. POEMS syndrome is a rare paraneoplastic syndrome due to an underlying plasma cell neoplasm. © 2020 BioMed Central Ltd unless otherwise stated.

You can also search for this author in Name must be less than 100 characters Epub 2014 Feb 17.Adam Z, Pour L, Krejčí M, Zahradová L, Szturz P, Koukalová R, Rehák Z, Nebeský T, Hájek R, Král Z, Mayer J.Sex Med Rev.