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A resistance gene, tetY, was found on an IncQ plasmid in E. coli independent of tetR, and a dysfunctional Tc r operon was identified on the chromosome of Agrobacterium tumefaciensC58 . tet.

& Scott, K. P. Comparative analysis of sequences flanking tet(W) resistance genes in multiple species of gut bacteria. Thirty-eight acquired tetracycline resistant (Tc(r)) genes are known of which nine are new and include five genes coding for energy-dependent efflux proteins, two genes coding for ribosomal protection proteins, and two genes coding for tetracycline inactivating enzymes. Gene. Qing-Bin Yuan, Ya-Meng Huang, Wen-Bin Wu, Pengxiao Zuo, Nan Hu, Yong-Zhang Zhou, Pedro J.J. Alvarez. Consecutive human bifidobacteria isolates and acquired tet genes.

and H.Y. Please enable it to take advantage of the complete set of features! Antibiotic resistance genes harbored by bifidobacteria are transferred from other bacteria.

This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. Gene. Guidance on the assessment of bacterial susceptibility to antimicrobials of human and veterinary importance. & Mayo, B.

Therefore, this study was performed to assess 92 bifidobacterial strains isolated from the feces of 14 healthy individuals, one type strain and seven commercial strains via phenotypically and genotypically screening the acquired tetracycline resistance profiles and to comparatively analyze the upstream and downstream sequences flanking the tetracycline resistance genes harbored by different strains.The MIC values of tetracycline in the 100 bifidobacterial strains tested are presented in Tables Genetic organization of the regions upstream and downstream of Genetic organization of the regions upstream and downstream of Genetic organization of the regions upstream and downstream of In our previous investigation of a collection of 92 bifidobacterial strains originating from the human GIT, the macrolide, lincosamide, and streptogramin (MLS) resistance gene It has been generally considered that the AR resistance genes carried by bifidobacteria are transferred from other bacteria in the human GIT via a number of complex mechanismsBecause bifidobacteria rarely harbor plasmids, it is generally believed that the acquired AR genes tend to be integrated into the chromosome of bifidobacteriaCommercially used bifidobacterial strains are commonly screened from the healthy human GITIn summary, this study has provided additional genetic knowledge regarding acquired tetracycline resistance in bifidobacteria isolated from the healthy human GIT.

Rolain, J. M. Food and human gut as reservoirs of transferable antibiotic resistance encoding genes.

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designed experiments.

the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Final approval was obtained from the Research Ethics Committee of Shanghai Jiaotong University, China. 2004 Aug 1;237(1):147-56. doi: 10.1016/j.femsle.2004.06.026.Akya A, Chegenelorestani R, Shahvaisi-Zadeh J, Bozorgomid A.Risk Manag Healthc Policy.

Aires, J., Thouverez, M., Doucet-Populaire, F. & Butel, M. J. This work was supported by Shanghai Industry-University Joint Research Program [grant number HU CXY-2016-010].State Key Laboratory of Microbial metabolism, and School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, P.R. Florez, A. The methods were carried out in accordance with the approved guidelines.

2008 May;282(2):147-59. doi: 10.1111/j.1574-6968.2008.01145.x.

Function i.

Huddleston, J. R. Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes. wrote the manuscript.The authors declare that they have no competing interests. Wiley The number of inactivating enzymes has increased from one to three, suggesting that work needs to be done to determine the role these enzymes play in bacterial resistance to tetracycline. Get the most important science stories of the day, free in your inbox.

To obtain & Dicks, L. M. Horizontal gene transfer amongst probiotic lactic acid bacteria and other intestinal microbiota: what are the possibilities?

Occurrence of the new tetracycline resistance gene tet(W) in bacteria from the human gut.

Organism. Vincent, D., Roy, D., Mondou, F. & Dery, C. Characterization of bifidobacteria by random DNA amplification. 2020 May 24;20(1):127. doi: 10.1186/s12866-020-01793-9.Møller TSB, Liu G, Hartman HB, Rau MH, Mortensen S, Thamsborg K, Johansen AE, Sommer MOA, Guardabassi L, Poolman MG, Olsen JE.Sci Rep. 2020 May 21;10(1):8438. doi: 10.1038/s41598-020-64995-1.

Ruiz-Moyano, S., Martin, A., Benito, M. J. Anaerobe. Resistance to tetracycline by an active tetracycline efflux. Status.

Antibiotics released to the environment can act as a selection pressure to promote the generation and development of ARGs and ARB.

Analysis of tetracycline resistance tet(W) genes and their flanking sequences in intestinal Bifidobacterium species.

ChinaInstitute of Bio-medicine, Shanghai Jiao Da Onlly Company Limited, Shanghai, 200233, P. R. ChinaYou can also search for this author in

Scott, K. P., Melville, C. M., Barbosa, T. M. & Flint, H. J.

2012CB720802). Antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) have been a global public health problem (Liu et al., 2018; Zhou et al., 2018).