This site uses cookies. As an outpatient, he had been stably maintained on bupropion for long-standing depression; this drug was continued throughout his hospital course. These interactions typically involve physicochemical reaction and inactivation between the nutrient(s) and the drug (4, 5). Specifically, it is the interactions that occur either in the delivery device or gastrointestinal lumen that are potentially being avoided (3). Bupropion is an antidepressant that, in concert with its primary metabolite hydroxybupropion, acts as a norepinephrine reuptake inhibitor as well as a mild dopamine reuptake inhibitor.However, linezolid clearly resembles the stronger monoamine oxidase inhibitors in its capacity to interact adversely with certain drugs.

If you experience headache, dizziness, or blurred vision, contact your doctor. nutrient interactions. The unexpected hemodynamic lability was severe enough to result in an unplanned admission to the intensive care unit, where the patient had an unremarkable postoperative course.The possibility of a significant drug interaction between linezolid and bupropion was suspected immediately and is supported by a careful analysis of the underlying pharmacologic mechanisms. Br J Pharmacol 1963; 21:403-13. Do not start, stop, or change the dosage of any medicine before checking with them first.Selected from data included with permission and copyrighted by First Databank, Inc.

A recent case of serotonin syndrome was reported with concur- rent use of linezolid and methadone. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. Clin Infect Dis 2003; 36:1197Phenelzine [package insert]. The effects of bretylium and guanethidine on the pressor responses to noradrenaline and angiotensin. Drug Saf 1992; 7:190–9Bodner RA, Lynch T, Lewis L, Kahn, D: Serotonin syndrome. His intraoperative course was notable for several episodes of severe hypertension (as high as 260/145 mmHg), despite an otherwise stable anesthetic. An Overview of Interactions With Zyvox Zyvox ® can potentially react with a number of other medications.Because there are so many Zyvox drug interactions that may be dangerous, it is important to check with your healthcare provider before taking any medications, whether prescription or over-the-counter (OTC), while you are taking Zyvox.

J Clin Pharmacol 2001; 41:563–72Breslow MJ: Clinical implications of the stress response to surgery: Principles and Practice of Anesthesiology, 2nd edition. In most cases, the primary concern is the impaired

MAO is a complex enzyme system in the body and inhibition of MAO can result in an increased concentration of neurotransmitters (e.g. Both linezolid and St John's wort can increase the risk of serotonin syndrome. Kalamazoo, MI: Pharmacia and Upjohn Company, 2001French G: Safety and tolerability of linezolid. * University of Maryland Medical System and Baltimore Veterans Administration Hospital. J Clin Psychopharmacol 1993; 13:312–20Sporer A: The serotonin syndrome: Implicated drugs, pathophysiology and management. Edited by Longnecker DE, Tinker JH, Morgan GE. However, linezolid clearly resembles the stronger monoamine oxidase inhibitors in its capacity to interact adversely with certain drugs.

J Antimicrobial Chemother 2003; 51(Suppl 2):II45–53Wellbutrin [package insert].

These medicines may cause some risk when taken together.

Zyvox (linezolid): Drug Safety Communication - Serious CNS Reactions Possible When Given to Patients Taking Certain Psychiatric Medications.

Your dose of guanethidine may need adjusting. Research Triangle Park, NC: GlaxoSmithKline, 2001Graber MA, Hoehns TB, Perry PJ: Sertraline-phenelzine drug interaction: A serotonin syndrome reaction.