syn - and (−)- Tingting Mo. The asymmetric total synthesis of the (+)-enantiomer of mefloquine hydrochloride is described. Concise Synthesis and Antimalarial Activity of All Four Mefloquine Stereoisomers Using a Highly Enantioselective Catalytic Borylative Alkene Isomerization. |  Match Criteria: Description system. Synthesis of Pentafluorosulfanyl Analogs of Mefloquine . To make an accurate diagnosis, the physician might also do a chest x-ray or possibly a blood test to see if your white blood count chloroquine quinine mefloquine is elevated. 2012 Jan 1;20(1):243-8. doi: 10.1016/j.bmc.2011.11.006. A Concise and Highly Enantioselective Total Synthesis of (+)- Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death. BD101. The pluses and minuses of mefloquine: A highly enantioselective catalytic borylative isomerization/aldehyde allylboration method for the stereoselective synthesis of the antimalarial drug mefloquine was optimized, thus leading to an efficient synthesis of all four mefloquine stereoisomers and analogues (see scheme). Background and Introduction: Mefloquine, a drug used to prevent and treat malaria is described possessing activity against the Mycobacterium tuberculosis (Mtb) as well as against multidrugresistant tuberculosis (MDR) and other types of bacteria. by . ]quinoline-1,3-diones and Their Antibacterial Activities A Concise and Highly Enantioselective Total Synthesis of (+)- 1. Bachelor of Science, Nanjing University, 2007 . redistribute this material, requesters must process their own requests via the RightsLink permission Mohan Pal, Gautam Srivastava, Lomary S. Moon, Ravinder S. Jolly. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username *Please select more than one item to compare The Absolute Configuration of (+)- and (−)- Knoevengal Condensation 2012;12(7):729-34. doi: 10.2174/156802612799984544.Dos Santos Fernandes GF, Jornada DH, de Souza PC, Chin CM, Pavan FR, Dos Santos JL.Curr Med Chem. The corticosteroids kill and suppress the function of lymphocytes. , Synthesis and Antibacterial Activity of Mefloquine-Based Analogs Against Sensitive and Resistant Mycobacterium tuberculosis Strains, Quinoline–1,2,3‐triazole Hybrids: Design and Synthesis through Click Reaction, Evaluation of Anti‐Tubercular Activity, Molecular Docking and In Silico ADME Studies, Thermodynamic analysis of a hybrid energy system using geothermal and solar energy sources with thermal storage in a residential building, Metal-Free Synthesis of 2-Fluoroalkylated Quinolines Using Polyfluoroalkanoic Acids as Direct Fluorine Sources, Attrition‐Enhanced Deracemization of the Antimalaria Drug Mefloquine, Attrition‐Enhanced Deracemization of the Antimalaria Drug Mefloquine, Asymmetric, efficient π-conjugated organic semiconducting chromophore for bulk-heterojunction organic photovoltaics, Friedlander synthesis of highly functionalized isoxazolyl quinoline libraries via addition of C(sp3)–H bond to aldehydes, Synthesis and antibacterial activity of oxazolidinone derivatives containing nitro heteroaromatic moiety, Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents, Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents, Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives, Targeting Phenotypically Tolerant Mycobacterium tuberculosis Roberto R. Gil, Christian Griesinger, Armando Navarro-Vázquez, Han Sun. M. Kohout, J. Vandenbussche, A. Roller, J. Tůma, J. Bogaerts, P. Bultinck, W. Herrebout, W. Lindner. from the ACS website, either in whole or in part, in either machine-readable form or any other form Despite their importance, few compounds based on the Mefloquine nucleus have been synthesized and evaluated against TB. *)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate Fluorinated Quinolines: Synthesis, Properties and Applications. The Absolute Configuration of (+)- and (−)- Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. Documentation: interaction is suspected, probable or established 1

erythro S ( Absolute configuration of the antimalarial erythro-mefloquine – vibrational circular dichroism and X-ray diffraction studies of mefloquine and its thiourea derivative. Lactobacillus paracasei not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information Structures of 4-{3-(X-phenyl)perhydro-1,3-oxazolo[3,4-a]pyridin-1-yl}-2,8-bis(trifluoromethyl)quinolines (X = H, 2-O