Press question mark to learn the rest of the keyboard shortcuts To our knowledge, this is the first published case report of migratory arthralgia and concomitant liver injury attributed to bicalutamide. (2015)' paper there are two cases listed for 10 mg/day CPA but the time the CPA was taken before diagnosis of meningioma for the two cases were in fact 5 years and 19 years. A number of adventurous clinicians began adopting bicalutamide in transfeminine people at this time and thereafter as well. The starting dose of Bica though is 50mg.

*Note that CPA does also function as a androgen receptor blocker, however the degree of AR blocking can be considered minimal at dosages of 6.25-25 mg/day. Bicalutamide, sold under the brand name Casodex among others, is an antiandrogen medication that is primarily used to treat prostate cancer. Regular liver function tests (LFT) and prolactin blood tests can provide a layer of safety. [29][7][30]" (However, the reality is that there are trans girls who took CPA from the outset of MtF HRT who have excellent breast development (and some who don't).Re bicalutamide: Of note, there is at least one trans girl on this sub who is close to first puberty and as per a recent update, was taking 100-150 mg/day bicalutamide.On the other hand, if a trans girl is already past first puberty and there is no risk of further masculinisation, then it probably doesn't matter so much if it takes a few extra months to find a way to get T down (with E2 taken as buccal, or via injections, etc) - or even if T is only partially blocked for a while. Of these, 3 were started on estrogen concurrently whereas 11 received bicalutamide alone, 7 of whom have returned for follow up thus far.

He had no other symptoms.

There seem to be more adhering to this perspective over on the Facebook HRT forum.Longer term, once T has been suppressed and can be maintained at castrate levels by E2 alone, bicalutamide may be particularly useful in regard of adrenally derived androgens: CPA works both by blocking the effects of androgens and, due to its very potent progestogenic activity, by powerfully suppressing levels of testosterone (For more information about bicalutamide please also see this thread: More detail and discussion from the three studies these tables are sourced from can be found in this thread Please note however, that each of the tables (which are from different studies) tend to list some of the same cases.Note that there appears to be a discrepancy between the meningioma case listed in this The first paper states the time of taking CPA 10 mg/day was 1 year to diagnosis of meningioma and is listed as:ter Wengel et al. In this type of scenario, lower dosages of bicalutamide (or spironolactone) can be utilised to block some T which hasn't yet been suppressed.But with either medication it makes sense to also utilise E2 levels to suppress T (unless a trans girl is specifically aiming at replicating cis female puberty, where E2 levels rise more slowly over time). By using our Services or clicking I agree, you agree to our use of cookies. 6.25-25 mg/day) make for an extremely effective T suppressor (antigonadotropin) and can significantly lower T within a few weeks.25 mg/day CPA can be expected to lower T by 70-80%, while 10 mg/day CPA would be expected to lower T by 60-70%. See However, there is limited published information as to how well bicalutamide works with trans girls close to first puberty (even in terms of clinical evidence). Anna Neyman, John Fuqua, and Erica Eugster @ Riley Children's Hospital in Indianapolis, Indiana, USA (Dr. Jessica Brooke Huffman @ 2BWell Clinic in Portland, Oregon, USA (Dr. Howard Rice @ Rice Medical Group in Mountain View, California, USA (Lyle "Cac" Cook, PA-C at St. John's Traynham in Los Angeles, California, USA (Dr. Negin Misaghian-Xanthos in Wilmington, North Carolina, USA (Dr. Lorraine Durand at the University Health Centre, University of Alberta, Canada (Dr. Lauren Gresham @ Nutima Integrative Medicine in Seattle, Washington, USA (Dr. L. Y. Louie Chan at the Church Wellesley Health Centre in Toronto, Ontario, Canada (If you know of any other clinicians that use or are willing to prescribe bicalutamide in transgender women, please let me know and I will add them here.Bicalutamide is widely used in the transgender do-it-yourself (DIY) community.

These differences are potentially more significant when it comes to trans girls close to first puberty.The doses of CPA which trans girls typically take (e.g. Such patients should be closely monitored for signs of deterioration and warned to contact their doctor immediately if their depression worsens. Bicalutamide is an anti-androgen. A 67-year-old male with metastatic prostate cancer presented with a 6-day history of migratory arthralgia. This thread is a collection of information on the topic of bicalutamide in transfeminine people. Further, even at higher dosages, CPA is not an efficient AR antagonist/blocker.I've used bica for a year and CPA for about two so hopefully I can give some context.

This may or may not be correct. I believe some would state that utilising only E2 (at high levels to suppress T) is entirely sufficient for trans girls close to first puberty. The only study at present is this one: New Study: Bicalutamide in MtF Adolescents (value as an AA & for promoting feminisation). This is what my doctor has me on but I never see any people talking about it.New comments cannot be posted and votes cannot be castA subreddit for informational posts, guides, and advanced discussion on transfeminine hormone therapy, otherwise known as male-to-female hormone replacement therapy (MtF HRT). Press question mark to learn the rest of the keyboard shortcutsCookies help us deliver our Services. Results: Of 77 patients with GD identified, 29 were MTF, of whom 14 (48%) aged 15.8 ± 1.9 years (range 12-18.4yr) were treated with bicalutamide 50 mg daily between 2013 and 2017.