Nitroglycerin may be used prophylactically 5 to 10 minutes prior to engaging in activities that might precipitate an acute attack. Excessive dosage of nitroglycerin may produce severe headaches.Nitroglycerin is a sublingual tablet and should not be chewed, crushed, or swallowed. Wall Chart - Oral Dosage Forms that Should Not be CrushedAlso known as the Look-alike and sound-alike (LASA) list. ... although not in the package insert, the drug has a coating that is intended to release the drug over approximately 3 hours. Cialis (tadalafil) is a prescription tablet used for erectile dysfunction and benign prostatic hyperplasia. Nitroglycerin Sublingual Tablets, USP (nahy-truh-glis-er-in) Read this information carefully before you start nitroglycerin sublingual tablets and each time you refill your prescription. Medications requiring special safeguards to reduce the risk of errors and minimize harm. 0.4 mg sublingual tablets are white to off-white, modified rectangle shaped tablets debossed with "CL" on one side and "4" on the other side and are supplied in bottles of 25 and 100 tablets. ­ If you have … The vasodilatory and hemodynamic effects of nitroglycerin may be enhanced by concomitant administration of aspirin. The dose may be repeated approximately every 5 minutes until relief is obtained. (Ed.). One tablet should be dissolved under the tongue or in the buccal pouch at the first sign of an acute anginal attack. The drug should be discontinued if blurring of vision or drying of the mouth occurs. Sometimes you can feel it in your shoulders, arms, neck, jaws, or back. It is not known if this effect occurs following single sublingual nitroglycerin doses. Angina feels like a pressing or squeezing pain, usually in your chest under the breastbone. /Length 4448 TEGRETOL® 100, 200 and 400 mg Tablets (carbamazepine) What you need to know about Tegretol Tablets . This may make dissolution of sublingual nitroglycerin difficult. If chewed and swallowed, may result in a lower peak concentration and bioavailability.Irritant; Note: chewed, crushed, or sucked tablets may cause oropharyngeal ulceration.Note: crushing the 23 mg tablet may significantly increase the rate of absorption; the 5 mg and 10 mg tablets are not affectedSlow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal dose.Slow-release; Note: chewed, cut, or crushed tablets may cause oropharyngeal irritationMucous membrane irritation; Note: drug may cause fetal abnormalities; women who are, or may become, pregnant, should not handle capsules; all women should use caution in handling capsules, especially leaking capsulesSublingual form (g); Note: chewing or swallowing may result in lower bioavailability.Note: chewed, crushed, or sucked tablets may cause oropharyngeal irritationAntineoplastic; Note: crushed or broken tablets should not be handledNote: chewing or swallowing may result in lower peak concentrations and bioavailabilitySlow-release; Note: may expose to potentially fatal overdoseNote: tablets should be dispersed completely in waterNote: although not in the package insert, the drug has a coating that is intended to release the drug over approximately 3 hoursNote: capsules may be opened and the contents mixed with food/drinkSlow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal dose.Slow-release (a) (Note: may add contents of capsule to chilled, not warm, applesauce and consume immediately)Slow-release; oral disintegrating tablet designed to disintegrate on the tongue.Taste; Note: capsule may be opened and mixed with fruit puree (e.g., banana)Note: drug may be crushed but company recommends using injectionNote: exposure to the powder may cause serious skin toxicities; health care workers should wear gloves to administerSlow-release (a); Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal doseNote: package insert indicates potential teratogenic effects; material safety data sheet warns against skin contact; health care workers should take appropriate precautionsSlow-release (Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal dose)Note: do not give as whole tablet, tablets are meant to be given as oral suspension; see company insertMucous membrane irritant; Note: may be dissolved in water or apple juiceNote: not scored; no studies available from companyNote: exposure to the powder may cause serious skin toxicities; health care workers should wear gloves to administerSlow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal doseAntineoplastic; Note: not scored; no studies available from companySlow-release (h); Note: 30mg tablet may not be splitNote: not scored; no studies available from companyNote: tablet should be swallowed whole and not crushed; tablet may be dispersed in waterNote: tablet may be dissolved in 4-8 ounces of waterNote: see prescribing information for making a suspensionMucous membrane irritant; Note: women who are, or may become, pregnant, should not handle crushed or broken tablets (l)Slow-release (a) (Note: do not give via NG tubes; crushing, chewing or dissolving tablets can cause rapid release and absorption of a potentially fatal dose)Note: not scored; no studies available from companyTaste (b) (Note: some extemporaneous formulas are pharmacy prepared)Slow-release (Note: tablet matrix may remain in stool)Slow-release (b); Note: crushing, chewing or dissolving tablets can cause rapid release and absorption of a potentially fatal doseSlow-release (b); Note: crushing, chewing or dissolving tablets can cause rapid release and absorption of a potentially fatal doseNote: crushing tablets has resulted in decreased bioavailability of drug (b)Slow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal doseSlow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal doseNote: not amenable to crushing; may obstruct feeding tubes (b)Slow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal doseNote: breaking, chewing, or emptying contents of the capsule can result in increased exposureNote: see package insert for administration instructions via an oral syringe of NG tubeNote: pharmacokinetics may be altered if not taken wholeNote: women who are, or may become, pregnant, should not handle crushed or broken tabletsNote: women who are, or may become, pregnant, should not handle crushed or broken tabletsNote: pharmacokinetic parameters may be affected (b)Slow-release; Note: delayed release is dependent on an intact coating (b)Note: Teratogenic potential; health care workers should avoid contact with capsule contents/body fluidsNote: an oral powder is available, see prescribing information for administration instructionsNote: tablets are not scored and cutting may cause variable dosage accuracyNote: exposure to the powder may cause serious skin toxicities; health care workers should wear gloves to administerFilm-coated (Note: active ingredients are surrounded by wax matrix to prevent healthcare exposure; women who are, or may become, pregnant should not handle crushed or broken tablet)Note: combining multiple tablets or portions of tablets may lead to an overdose of entacaponeNote: disruption of capsule may yield high blood levels causing enhanced toxicity (a)Empty contents into a spoon for administration.