After initial priming (6 actuations), each actuation delivers 50 mcg of fluticasone propionate in 100 mg of formulation through the nasal adapter. Before using FLONASE SENSIMIST, blow your nose gently to clear your nostrils. Put the tip of the spray bottle into your nostril and tilt your head forward while keeping the bottle, upright. Maximum effect may take several days and individual patients will experience a variable time to onset and different degree of symptom relief.The recommended starting dosage in adults is 2 sprays (50 mcg of fluticasone propionate each) in each nostril once daily (total daily dose, 200 mcg). Discontinuation rates and contraindicatio . Once adequate control is achieved, the dosage should be decreased to 1 spray in each nostril once daily.The maximum total daily dosage should not exceed 2 sprays in each nostril (200 mcg/day) There is no evidence that exceeding the recommended dose is more effective.This website is intended for informational and entertainment purposes only and is not intended to replace any professional medical advice.This field is for validation purposes and should be left unchanged. There is no evidence that exceeding the recommended dose is more effective.The recommended starting dosage in adolescents and children, aged 4 years and older is 1 spray in each nostril once daily (total daily dose, 100 mcg).

Once adequate control is achieved, the dosage should be decreased to 1 spray in each nostril once daily.The maximum total daily dosage should not exceed 2 sprays in each nostril (200 mcg/day) There is no evidence that exceeding the recommended dose is more effective.Administer FLONASE Nasal Spray by the intranasal route only. After the first few days, patients may be able to reduce their dose to 1 spray in each nostril once daily for maintenance therapy.Maximum total daily doses should not exceed 2 sprays in each nostril (total dose, 200 mcg/day). FLONASE nasal sprays act on multiple inflammatory substances (histamine, prostaglandins, cytokines, tryptases, chemokines, and … MedWatch Safety Alerts are distributed by the FDA and published by Drugs.com. Be sure to aim slightly away from the center of your nose. Patients not adequately responding to 1 spray in each nostril may use 2 sprays in each nostril once daily (total daily dose, 200 mcg). Also, most formulations of the medicine are not safe or effective in children under the age of 4. Following is a list of possible medication recalls, market withdrawals, alerts and warnings.

During postmarketing use, there have been reports of clinically significant drug interactions in patients receiving fluticasone propionate and ritonavir, resulting in systemic corticosteroid effects including Cushing syndrome and adrenal suppression. The FDA Alert(s) below may be specifically about Flonase Sensimist or relate to a group or class of drugs which include Flonase Sensimist (fluticasone). How the dose, route, and duration of corticosteroid administration affect the risk of developing a disseminated infection is not known. (See the respective package inserts for complete VZIG and IG prescribing information.) Some of the dosage forms listed on this page may not apply to the brand name Flonase Sensimist.. After the first few days, patients may be able to reduce their dose to 1 spray in each nostril once daily for maintenance therapy.Maximum total daily doses should not exceed 2 sprays in each nostril (total dose, 200 mcg/day). Chickenpox and measles, for example, can have a more serious or even fatal course in susceptible children or adults using corticosteroids. Patients not adequately responding to 100 mcg may use 200 mcg (2 sprays in each nostril). If exposed to measles, prophylaxis with pooled intramuscular immunoglobulin (IG) may be indicated. In those patients who have asthma or other clinical conditions requiring long-term systemic corticosteroid treatment, too rapid a decrease in systemic corticosteroids may cause a severe exacerbation of their symptoms.The concomitant use of intranasal corticosteroids with other inhaled corticosteroids could increase the risk of signs or symptoms of hypercorticism and/or suppression of the HPA axis.A drug interaction study in healthy subjects has shown that ritonavir (a highly potent cytochrome P450 3A4 inhibitor) can significantly increase plasma fluticasone propionate exposure, resulting in significantly reduced serum cortisol concentrations (see CLINICAL PHARMACOLOGY: Drug Interactions and PRECAUTIONS: Drug Interactions).