Talk to your doctor about other options that may work for you.© 2005-2020 Healthline Media a Red Ventures Company. Some people may take as little as 25 mg per day or as much as 200 mg per day.This medication isn’t approved for use in children younger than 18 years.There are no specific recommendations for senior dosing. Your doctor will tell you what dosage is right for you. Adult dosage (ages 18 to 64 years) Typical starting dosage: 75 mg per day. A normal adult dose may cause levels of this drug to be higher than normal in your body. A few studies in the current review included examination of drug-drug interactions with CBD. Adjust as necessary, upward or downward, whenever your body feedback- or your intuition- indicates that a change is needed.

The issue is that CBD is metabolized by cytochrome P450 enzymes, occupying the site of enzymatic activity and preventing it from metabolizing other compounds or pharmaceuticals. Standard doses are the mid-range, between 10 mg to 100 mg of CBD per dose per day.Standard doses have been shown to be effective for pain, inflammation, autoimmune disorders, Lyme disease, anxiety, depression, arthritis, some mental disorders, fibromyalgia, multiple sclerosis, inflammatory bowel syndrome, autism, and weight loss.Macro or therapeutic doses are at the higher range, between 50 mg and 800 mg of Doses at this level are often used in cancer, epilepsy, seizure disorders, liver disease, and other severe life-threatening conditions. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.There are other drugs available to treat your condition. In cannabis therapy, we often find that “less is more”. If you’re a senior, you may need a lower dose or a different dosage schedule.Spironolactone is used for long-term treatment. It’s given as a single dose or split into two doses.This medication isn’t approved for use in children younger than 18 years.There are no specific recommendations for senior dosing. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.Examples of drugs that can cause interactions with spironolactone are listed below.Taking certain medications with spironolactone can increase the amount of potassium in your body to unsafe levels. CBD will inhibit the CYP 450 enzyme, which results in a slower excretion rate of caffeine = prolonged effects of caffeine.A systematic review in 2014 concluded that CBD generally has a low risk of clinically significant drug-interactions (). © 2005-2020 Healthline Media a Red Ventures Company. GW Pharmaceuticals performed a clinical trial investigating the pharmacokinetic interaction between CBD/THC spray (sativex) and rifampicin (cytochrome P450 inducer), ketoconazole, and omeprazole (cytochrome P450 inhibitors) (Authors concluded overall that CBD in combination with the drugs were well-tolerated, but consideration should be noted when co-administering with other drugs using the CYP3A4 pathway.https://www.frontiersin.org/articles/10.3389/fphar.2018.01365/full*This content is strictly the opinion of Dr. Frank Michalski and is for informational and educational purposes only. Your doctor may increase or decrease your dosage based on how you respond to the drug. If you are taking, for example, a benzodiazepine medication and CBD or a chemotherapy drug and CBD you may be at risk. We do not have the clinical trials to further support any other commentary at this time. “Titration is a term borrowed from chemistry that means taking small steps over time in order to allow for adjustments slowly. If your medication uses the CYP 450 2C19 enzyme use caution (google this information or speak with a pharmacist). We always recommend titration as the best way to introduce CBD to the body. Each milliliter (mL) contains 5 mg diazepam; 40% propylene glycol; 10% alcohol; 5% sodium benzoate and benzoic acid added as buffers; and 1.5% benzyl alcohol added as a preservative. A normal adult dose may cause levels of this drug to be higher than normal in your body.