View filters. It is used to treat fibrocystic breast disease.
Danazol Source guidance details Guidance: Heavy menstrual bleeding: assessment and management (CG44) Published date: December 2016 Paragraph number: 1.5.14 Page number: 12 View all NICE do not do from this Guidance.
Severe pain and tenderness in benign fibrocystic breast disease not …
Results for danazol 1 - 10 of 189 sorted by relevance / date. It is used to treat swelling attacks in people with hereditary angioedema (HAE). Filter by NICE advice (1) Status Filter by ... 5 results for danazol. [2007]Dilatation and curettage should not be used as a therapeutic treatment. Last revised in November 2018. NICE; CKS; Topics A to Z; Angio-oedema and anaphylaxis; Angio-oedema and anaphylaxis. Topics A to Z; Specialities; What's new; About CKS; Journals and databases; Read about our approach to COVID-19. [2007]Measuring menstrual blood loss either directly (alkaline haematin) or indirectly ('Pictorial blood loss assessment chart') is not routinely recommended for HMB. It is taken by mouth. Uses of Danazol: It is used to treat endometriosis. [2007]Oral progestogens given during the luteal phase only should not be used for the treatment of HMB. Download. 200–800 mg daily in up to 4 divided doses usually for 3–6 months, dose to be adjusted to achieve amenorrhoea, in women of child-bearing potential, treatment should start during menstruation, preferably on day 1. Danazol potentially increases the anticoagulant effect of acenocoumarol. [2007]In fluid-filled thermal balloon endometrial ablation (TBEA), endometrial thinning is not needed. [2007]A serum ferritin test should not routinely be carried out on women with HMB.
Danazol, sold as Danocrine and other brand names, is a medication used in the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema and other conditions.
Last revised in February 2020. Danazol should not be used routinely for the treatment of HMB. NICE guidance; Standards and indicators; Evidence search; BNF; BNFC; CKS. [2007]Use of NSAIDs and/or tranexamic acid should be stopped if it does not improve symptoms within 3 menstrual cycles. Danazol was discovered in 1963 and was introduced for medical use in 1971.Androgenic side effects are of concern, as some women taking danazol may experience unwanted hair growth (The use of danazol for endometriosis has been linked to an increased risk of Danazol is described as a possessing high affinity for the For reference, circulating concentrations of danazol are in the range of 2 μM at a dosage of 600 mg/day in women.Danazol is known to bind to two steroid hormone carrier proteins: As can be seen, the percentage of free testosterone is tripled in women being treated with danazol.It is noteworthy that 2-hydroxymethylethisterone, a major metabolite of danazol, circulates at concentrations 5–10 times greater than those of danazol and is twice as potent as danazol in displacing testosterone from SHBG.Via its weak progestogenic and androgenic activity, through activation of the PR and AR in the Because danazol reduces estrogen production and levels,In men, danazol has been found to inhibit gonadotropin secretion and markedly decrease testosterone levels, likely due to its actions as a steroidogenesis inhibitor and antigonadotropin.Danazol, also known as 2,3-isoxazol-17α-ethynyltestosterone or as 17α-ethynyl-17β-hydroxyandrost-4-en-[2,3-d]isoxazole, is a Danazol is or has been marketed under many brand names throughout the world including Anargil, Azol, Benzol, Bonzol, Cyclolady, Cyclomen, Danal, Danalol, Danamet, Danamin, Danasin, Danatrol, Danazant, Danazol, Danocrine, Danodiol, Danogen, Danokrin, Danol, Danonice, Danoval, Danzol, Dogalact (Low-dose danazol has been investigated in the treatment of A 2016 phase I/II prospective study orally administered 800 mg per day to 27 patients with C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC5=C(C[C@]34C)C=NO5InChI=1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,17+,18+,20+,21+,22+/m1/s1Other sex hormones and modulators of the genital system (
[2007]Saline infusion sonography should not be used as a first-line diagnostic tool.Magnetic resonance imaging (MRI) should not be used as a first-line diagnostic tool.
Measuring menstrual blood loss either directly (alkaline haematin) or indirectly ('Pictorial blood loss assessment chart') is not routinely recommended for HMB.
Topics A to Z; Specialities; What's new; About CKS; Journals and databases; Read about our approach to COVID-19. Evidence-based information on danazol from hundreds of trustworthy sources for health and social care. Whether menstrual blood loss is a problem should be determined not by measuring blood loss but by the woman herself.
[2007]If a woman is being treated with gonadotrophin-releasing hormone analogue and UAE is then planned, the gonadotrophin-releasing hormone analogue should be stopped as soon as UAE has been scheduled.
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[2007] [2007]Female hormone testing should not be carried out on women with HMB. [2007]Dilatation and curettage alone should not be used as a diagnostic tool. [2007]Etamsylate should not be used for the treatment of HMB. NICE; CKS; Topics A to Z; Endometriosis; Endometriosis. [2007]Danazol should not be used routinely for the treatment of HMB. Manufacturer makes no recommendation. [2007]Hysterectomy should not be used as a first-line treatment solely for HMB.Removal of healthy ovaries at the time of hysterectomy should not be undertaken.