Contact with water while bathing, swimming, showering or exercising will not change the effect of OXYTROL.A new application site should be selected with each new system to avoid re-application to the same site within 7 days. Similar to the pharmacokinetic studies, > 98% of the systems evaluated in the pivotal studies were assessed as being ≥ 75% attached and thus would be expected to perform as anticipated. Tablets (immediate release): 5 mg; Tablets (extended release): 5, 10, and 15 mg; Transdermal delivery system or patch: 3.9 mg/day; Syrup: 5 mg/5 ml. It is not known if OXYTROL is safe and effective in children. No overall differences in safety or effectiveness were observed between these patients and younger patients, and other reported clinical experience has not identified differences in response between elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out [see The plasma concentration of oxybutynin declines within 1 to 2 hours after removal of transdermal system(s). A total of 411 patients entered the open-label extension and of those, 65 patients and 52 patients received Oxytrol for at least 24 weeks and at least 36 weeks, respectively.No deaths were reported during treatment. These doses are approximately 6, 25 and 50 times the maximum exposure in humans taking an oral dose based on body surface area.Oxybutynin chloride showed no increase of mutagenic activity when tested in The efficacy and safety of Oxytrol were evaluated in patients with urge urinary incontinence in two controlled studies and one open-label extension. Other drugs may interact with oxybutynin, including prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Oxytrol only for the indication prescribed..Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2020 Cerner Multum, Inc. Oxybutynin is a medicine that helps relax the bladder muscle, reducing urges and leakage. Layer 1 (Backing Film) is a thin flexible polyester/ethylene-vinyl acetate film that provides the matrix system with occlusivity and physical integrity and protects the adhesive/drug layer. Oxytrol in pill form by prescription will still be available. Site by These doses are approximately 6, 25 and 50 times the maximum exposure in humans taking an oral dose based on body surface area.Oxybutynin chloride showed no increase of mutagenic activity when tested in Risk Summary There are no studies with topical or oral oxybutynin use in pregnant women to inform a drug associated risk for birth defects or In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20% respectively.Subcutaneous administration of oxybutynin chloride to rats at doses up to 25 mg/kg (approximately 50 times the human exposure based on surface area) and to rabbits at doses up to 0.4 mg/kg (approximately 1 times the human exposure based on body surface area) throughout the period of organogenesis revealed no evidence of harm to the fetus.Risk Summary There is no information on the presence of oxybutynin in human milk, the effects on the breastfed child, or the effects on milk production. Following removal of OXYTROL, plasma concentrations of oxybutynin and Ndesethyloxybutynin decline with an apparent half-life of approximately 7 to 8 hours.Oxybutynin is extensively metabolized by the liver, with less than 0.1% of the administered dose excreted unchanged in the urine. Average steady-state plasma concentrations were 3.1 ng/mL for oxybutynin and 3.8 ng/mL for N-desethyloxybutynin (Figure 3). Do not use the same skin area twice within 7 days.Use baby oil or mild soap and water to remove any adhesive residue that stays on your skin. In the two pivotal studies, a total of 246 patients received Oxytrol during the 12-week treatment periods. Use a calendar to help you keep a steady patch-changing schedule.Choose a different place on your skin to wear the patch each time you put on a new one. Does Albuterol Come In Pill Form. Flonase (fluticasone propionate) does not come in a pill form. Layer 2 (Adhesive/Drug Layer) is a cast film of acrylic adhesive containing oxybutynin and triacetin, USP. Layer 1 (Backing Film) is a thin flexible polyester/ethylene-vinyl acetate film that provides the matrix system with occlusivity and physical integrity and protects the adhesive/drug layer. Avoid using harsh soaps, alcohol, nail polish remover, or other solvents that could irritate your skin.After removing a patch, fold it in half so it sticks together and throw it away in a place where children or pets cannot get to it.The Oxytrol patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging).