Cigarette smoking increases theophylline clearance and shortens its serum half-life.No further relevant information other than that which is included in other sections of the Summary of Product Characteristics.Incompatibility has been reported with chlorpromazine, clindamycin, corticotrophin, dimenhydrinate, doxorubicin, erythromycin gluceptate, hydralazine hydrochloride, hydroxyzine hydrochloride, opioid analgesics, oxytetracycline hydrochloride, phenytoin sodium, procaine hydrochloride, prochlorperazine salts, promazine hydrochloride, promethazine hydrochloride, sulphafurazole diethanolamine and vancomycin hydrochloride. By continuing to browse the site you are agreeing to our policy on the use of cookies.
Increased risk of cardiac arrhythmias (see also hypokalaemia). ▪ Antiepileptics (e.g. Check with your doctor right away if you have burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. In addition, adult and pediatric patients with leukemia can develop a significant level of iron-overload during, and as result of, chemotherapy [The precise control of calcium levels during the contraction-relation cycle in cardiomyocytes is extremely important for normal beat-to-beat contractile activity [Moreover, normal calcium homeostasis is altered by ROS and hydrogen peroxide via disruption of normal sarcoplasmic reticulum function. It is the late-starting damage that is important and more serious. In medical terms, this is called the ‘left ventricular ejection fraction’ or LVEF. This medicine can cause changes in your heart rhythm, such as a condition called QT prolongation. Increased risk of convulsions with ketamine; increased risk of arrhythmias with halothane. )GoodRx provides no warranty for any pricing data or other information. Numerous factors increase the chances of heart damage with doxorubicin. Continue typing to refine. In this case, cardiac transplantation remains a vital option for patients with end-stage heart failure due to DOX-induced cardiomyopathy [In this scenario, in which therapeutic options for DOX-induced cardiomyopathy are insufficient, a newly emerging strategy is cell therapy. Cardiac toxicity can often be prevented by giving less of the cancer drug. It has stimulant effect on respiration, and also a diuretic action of short duration.Theophylline is approximately 60% bound to plasma proteins but binding is decreased to about 40% in neonates and in adults with hepatic disease. carbamazepine, phenytoin, primidone, phenobarbitone) Concurrent use of other xanthine derivatives, including theophylline and pentoxifylline are contraindicated due to the risk of toxicity. Obtain baseline and periodic liver transaminases and discontinue or reduce dose if the increase exceeds three times normal, or doubles in a patient with an elevated baseline. 250mg.Clear, sterile solution for injection, intended for parenteral administration to human beings.Aminophylline is a complex of theophylline and ethylenediamine and is given for its theophylline activity to relax smooth muscle and to relieve bronchial spasm.Aminophylline Injection is indicated for relief of bronchospasm associated with asthma and in chronic obstructive pulmonary disease.Maintenance therapy can be administered via larger volume infusion solutions, rate-regulated to deliver the required amount of drug each hour.Therapeutic plasma concentrations of theophylline are considered to be in the range of 5 to 20mcg/ml and levels above 20mcg/ml are more likely to be associated with toxic effects.