... Drug interactions with fluconazole oral and tacrolimus … Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media; Slideshows Images Quizzes. Antimalarials Mefloquine, quinine, quinidine é CsA or TAC concentration Additive QTc prolongation due to tacrolimus with anti-malarials Closely monitor CsA or TAC serum concentration.

Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. The use of prophylactic antifungal therapy is suggested after kidney transplantation.

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The dosing could be optimized according to trough concentration, even in the presence of fluconazole.

Clin Pharmacokinet. Please enable it to take advantage of the complete set of features! This association leaded to an increase in tacrolimus concentration (1.33 to 2.45 times the initial concentration) in all patients. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media; Slideshows Images Quizzes. This severe interaction is clinically important and more pronounced than earlier described interactions with tacrolimus and other azole drugs. Epub 2019 Oct 26.Uno T, Wada K, Matsuda S, Ikura M, Takenaka H, Terakawa N, Oita A, Yokoyama S, Kawase A, Hosomi K, Takada M.Br J Clin Pharmacol. Fluconazole, an azole antifungal agent, affects blood concentration of tacrolimus by inhibiting the cytochromes P450 (CYP) 3A4 and 3A5.

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Monitor for QTc prolongation if antima-larial treatment must be initiated in a patient receiving tacrolimus. Dustri-Verlag Dr. Karl Feistle GmbH & Co. KG

By the risk of drug interaction occurrence, tacrolimus doses were decreased by two thirds in one case and by the third in the second case.

Background.

This tool may not cover all possible drug interactions.

However, efficacy of low‐dose (50 mg) oral fluconazole and its effect on tacrolimus trough levels in patients maintained on tacrolimus and mycophenolic acid, with or without corticosteroids, is unknown.

Never use this combination of drugs because of high risk for dangerous interactionPotential for serious interaction; regular monitoring by your doctor required or alternate medication may be neededPotential for significant interaction (monitoring by your doctor is likely required)Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. 2008 Nov;42(11):1711-6. doi: 10.1345/aph.1L330.

Epub 2008 Sep 23.Deininger KM, Vu A, Page RL 2nd, Ambardekar AV, Lindenfeld J, Aquilante CL.Clin Transplant. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. This site needs JavaScript to work properly.

2008 Jan;64(1):89-91. doi: 10.1007/s00228-007-0395-0. Therefore, to avoid overexposure during everolimus-azole cotreatment, the dose of everolimus should be reduced. Learn about drug interactions between fluconazole oral and tacrolimus top and use the RxList drug interaction checker to check drug combinations.