In the WebMD Lupus Community, Christine Miserandino discusses work issues, the decision to seek disability, and the ins and outs of the application process. by Erin White . Or view hourly updated newsfeeds in your RSS reader:Keep up to date with the latest news from ScienceDaily via social networks:Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Steven Wright 0 Comments Updated: December 11, 2018 Autoimmunity. Celebrities like … It works in everybody. This is the goal for most people with lupus, but is not possible in every case. "Putting Lupus in permanent remission." Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. View Conditions A to Z » Support Forums. "It is our hope that the next step is a phase one clinical trial in humans to show the efficacy of the peptide therapy in patients with lupus," Datta said. In other people, lupus will remain in a chronic (long-lasting) state of activity. Datta's team identified the peptides used in this study in 1996, and Northwestern University holds the intellectual rights to these patented discoveries but has published the sequences of the peptides for open access to everyone. www.sciencedaily.com/releases/2013/11/131111161512.htm (accessed September 11, 2020).Below are relevant articles that may interest you. Show More . The study was published online in Clinical Immunology.
According to the Lupus Foundation of America, it is believed that 5 million people throughout the world have a form of lupus.In past studies, Northwestern scientists showed that a nontoxic therapy (which uses synthetic peptides -- small bits of protein -- to generate special regulatory T cells) blocks lupus in mice that are prone to the disease.For this new study, 30 lupus patients (10 active and 20 in remission) and 15 healthy patients were enrolled and their blood samples were cultured with low doses of the special peptides. Much like chemotherapy, lupus drugs can compromise fertility and weaken the immune system, making it difficult for patients to have children and leaving their bodies susceptible to infections. Northwestern Medicine® scientists have successfully tested a nontoxic therapy that suppresses Lupus in blood samples of people with the autoimmune disease.This is a positive step toward one day developing a vaccine-like therapy that could keep Lupus in remission in the human body without the use of toxic drugs.Lupus is a chronic, autoimmune disease that causes the body to create autoantibodies that attack and destroy healthy tissue and cause inflammation, pain and damage in various vital organs of the body. Eating healthy, protecting against sun exposure, avoiding environmental toxins, maintaining a low stress level, getting plenty of rest, and avoiding certain medications like sulfa drugs can all help in keeping lupus in remission. Northwestern University. During remission, you may still need certain medications. Putting Lupus in permanent remission Date: November 11, 2013 Source: Northwestern University Summary: Scientists have successfully tested a nontoxic therapy that suppresses Lupus … Much like chemotherapy, lupus drugs can compromise fertility and weaken the immune system, making it difficult for patients to have children and leaving their bodies susceptible to infections. When a person is in remission while taking medications, doctors always try to taper steroid use down to the lowest possible dose, and, if possible, to stop using them. Questions?Northwestern University. "It can be given to both subjects with and without lupus and boost their regulatory response with no side effects.
"Datta is a professor of medicine-rheumatology and microbiology-immunology at Northwestern University Feinberg School of Medicine.Steroids and Cytoxan are the most common therapies used to help treat people with lupus and even at very low doses the side effects of the drugs are toxic.
Northwestern Medicine® scientists have successfully tested a nontoxic therapy that suppresses lupus in human blood samples, which may lead to a vaccine-like therapy that could keep the autoimmune disease in remission.Lupus is a chronic condition that causes the body to create autoantibodies that attack and destroy healthy tissue and cause inflammation, pain and damage to the vital organs. Non-steroidal anti … Although remission is the goal, it is a hard target to achieve. "This study relates to Datta's more than 27 years of research in the lupus field focused on the cloning of the T cells that drive lupus autoimmunity. In the Hopkins Lupus Cohort (over 2,000 patients), achieving LLDAS 50% of the time led to a 50% reduction in permanent organ damage. We don't have to design something specifically for an unusual person. The study was published online in Clinical Immunology, the journal of the Federation of Clinical Immunology Societies. Written by Landria Voigt. Partial lupus remission, which is a period in which a person experiences relief from lupus symptoms, is considered common. "It is our hope that the next step is a phase one clinical trial in humans to show the efficacy of the peptide therapy in patients with lupus," Datta said. ScienceDaily. Also, such toxic drugs cannot be given indefinitely. The reality is that although remission is the very best outcome for someone with lupus, it’s not nearly the same thing as a … Instead, the Lupus Low Disease Activity State (LLDAS) can be achieved three times more frequently. ScienceDaily. Also, such toxic drugs cannot be given indefinitely. "We found that the peptides could not only generate regulatory T cells, but also that they block and reduce autoantibody production to almost baseline levels in the blood cultures from people with active Lupus," said Syamal Datta, M.D., senior author of the study. Accepting our symptoms as a normal part of life can turn into permission to stop fighting. It works in everybody. "This nontoxic therapy works like a vaccine in that the peptides are recognized by the bodies of almost every individual we have seen," Datta said. It’s a tough question, but an important one.